Comparing Acute Mountain Sickness Definitions to Examine Differences in Systemic Inflammation
نویسندگان
چکیده
Acute mountain sickness (AMS) occurs when individuals rapidly ascend to high altitudes, but its exact cause remains unknown. Additionally, AMS is assessed using a subjective questionnaire with variety of criteria used for diagnosis so there no precise, objective method determining if subject has AMS. Hypoxia, or low oxygen, at altitude results in proinflammatory state and associated systemic inflammation as determined by elevated plasma levels some cytokines. Thus, we wanted determine the association between was altered based on how defined. To examine this, 17 women men were exposed 10 hours normobaric hypoxia (11.5% O2) simulating 15600 feet. Blood samples taken before assayed 13 inflammatory defined following definitions: 1) Lake Louise Questionnaire (LLQ) score ≥3 headache ≥1 10-hour time point, 2) maximum LLQ ≥1, 3) Environmental Symptoms (ESQ) 0.7 ≥3, ≥2, ESQ ≥0.4, 4) 5) point. We found that Interleukin (IL) 8 significantly increased AMS- not AMS+ participants regardless definition. IL-1β IL-33 concentration from baseline under only three out five definitions (#1, #3 & #5 above #3, #4, IL-33). Furthermore, change after different definition above. These data suggest may influence whether are differences circulating cytokines those without Therefore, relationship be more complex than previously thought.
منابع مشابه
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: ['0892-6638', '1530-6860']
DOI: https://doi.org/10.1096/fasebj.2021.35.s1.03330